專長及研究方向
1. 以果蠅 Border cells為生物模式研究細胞遷移及癌症轉移
2. 類固醇激素在胚胎發育及癌症轉移的功能
細胞遷移在生物學是一複雜且重要的研究課題,此一步驟影響層面極廣,包含胚胎發育時各胚層的遷移,發炎反應時免疫細胞如何迅速到達目的地以殺死入侵病源,個体受傷時的傷口癒合,甚至癌細胞的轉移, 這些都是我們有興趣的研究方向。本實驗室主要利用在果蠅一群會遷移的上皮細胞 (Border cells)為生物模式,研究細胞遷移及癌症轉移的分子機轉。
Drosophila ovary as a model system to study cell migration and metastasis
There are several features making Drosophila as a feasible model system to study human diseases. First, it is a genetically tractable organism with sophisticated tools to test genes’ functions. More importantly, nearly 75% of human disease genes have a Drosophila homologue and the conservation in signaling pathways provide promising approaches to test or design new drugs. The most prevailing aspect of this model system is the capability to do whole genome-wide forward genetic screen to seek for novel genes contributing to the pathogenesis of diseases. In our screen, we identified a few promising candidate genes, which might serve as novel potential targets for therapeutic design. Here, Drosophila oogenesis will be applied to study for cell migration and cancer metastasis. Ultimately, candidate genes identified in flies will be examined in mammalian cell lines or patient samples.
1. 以果蠅 Border cells為生物模式研究細胞遷移及癌症轉移
2. 類固醇激素在胚胎發育及癌症轉移的功能
細胞遷移在生物學是一複雜且重要的研究課題,此一步驟影響層面極廣,包含胚胎發育時各胚層的遷移,發炎反應時免疫細胞如何迅速到達目的地以殺死入侵病源,個体受傷時的傷口癒合,甚至癌細胞的轉移, 這些都是我們有興趣的研究方向。本實驗室主要利用在果蠅一群會遷移的上皮細胞 (Border cells)為生物模式,研究細胞遷移及癌症轉移的分子機轉。
Drosophila ovary as a model system to study cell migration and metastasis
There are several features making Drosophila as a feasible model system to study human diseases. First, it is a genetically tractable organism with sophisticated tools to test genes’ functions. More importantly, nearly 75% of human disease genes have a Drosophila homologue and the conservation in signaling pathways provide promising approaches to test or design new drugs. The most prevailing aspect of this model system is the capability to do whole genome-wide forward genetic screen to seek for novel genes contributing to the pathogenesis of diseases. In our screen, we identified a few promising candidate genes, which might serve as novel potential targets for therapeutic design. Here, Drosophila oogenesis will be applied to study for cell migration and cancer metastasis. Ultimately, candidate genes identified in flies will be examined in mammalian cell lines or patient samples.